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Understanding Brain Connectivity in Smokers and Drinkers: The Role of Impulsivity and the Potential of Brain Training

Introduction

The relationship between lifestyle choices and brain function has long intrigued scientists and health professionals alike. Of particular interest is the impact of high-risk behaviors such as smoking and drinking on the brain's intricate network of connections. Recent research by Cheng, Wei et al. reveals fascinating differences in brain connectivity between smokers, drinkers, and those who engage in both activities, uncovering a potential link to impulsivity.


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Dissecting the Brain's Wiring: Smokers vs. Drinkers

Cheng and colleagues took an in-depth look at the brain's functional connectivity—the pattern of communication between various brain regions—in individuals who smoke, drink, or do both. Their findings were striking: smokers showed reduced connectivity, particularly in regions associated with behavior change and impulsivity control, such as the lateral orbitofrontal cortex. Drinkers, on the other hand, exhibited increased connectivity in areas linked to reward processing, like the medial orbitofrontal cortex.


The Impulsivity Connection

What does this mean for the individual who smokes or drinks? At the heart of the matter is impulsivity. In both cases, the altered brain connectivity was associated with increased impulsiveness.


In the case of smokers, the noted decrease in connectivity suggests a potential compromise in the individual's ability to exercise behavioural inhibition, particularly in situations devoid of immediate rewards or involving punitive consequences. In other words, the weakened connections between relevant brain regions may contribute to challenges in exercising self-control and prudent decision-making among smokers.

Conversely, the focus on drinkers highlights an opposite trend – an increase in connectivity. This heightened connectivity is proposed to be linked to elevated sensitivity within the brain's reward system. The reward system plays a crucial role in experiencing pleasure and reinforcing certain behaviours. In the context of drinkers, the suggestion is that their brains exhibit a stronger response to the rewarding effects of alcohol. Consequently, this increased connectivity in reward-related brain regions may predispose drinkers to greater impulsivity, particularly in situations involving alcohol. The implication is that individuals with this heightened connectivity might be more prone to making impulsive decisions driven by the immediate pleasure associated with alcohol consumption, potentially overlooking or undervaluing the long-term consequences of their actions.


This contrasting picture raises important questions about the neurobiological underpinnings of these behaviours and their co-occurrence. Notably, the study found that the differences in connectivity were not just static snapshots but correlated with the frequency and amount of smoking and drinking.


The study also looked at young individuals and found that patterns of connectivity at age 14 could predict engagement in smoking or drinking by age 19, suggesting a potential causal role for these neural differences.


The Potential of Brain Training

In light of these findings, could brain training offer a ray of hope? Techniques like NeurOptimal® brain training might hold the key to mitigating the changes in connectivity observed in smokers and drinkers. NeurOptimal® is a non-invasive method that uses auditory cues to alert the brain to its own activity patterns. By interrupting music at specific moments, the brain is prompted to recognize and potentially correct its habitual patterns of function.

The promise of such technology lies in its ability to essentially 'teach' the brain to become more flexible and adaptable. As the brain learns to notice its own activity, it can strengthen the neural pathways associated with positive behaviors and weaken those tied to risky choices like smoking and drinking.


Conclusion

The study by Cheng, Wei et al. shines a light on the complex relationship between brain connectivity, risky behaviors, and impulsivity. While the association between altered functional connectivity and substance use is clear, the question of causality remains. Are these brain changes a result of smoking and drinking, or do they predispose individuals to these behaviors?


Regardless of the answer, interventions like NeurOptimal® brain training present a novel approach to addressing these changes. By harnessing the brain's own capacity for change, there is a potential to improve cognitive control, reduce impulsivity, and perhaps even alter the trajectory of substance use in individuals.


Future research will undoubtedly delve deeper into these connections, but for now, the message is one of cautious optimism. Understanding the brain's wiring gives us power—the power to change, to adapt, and to overcome the challenges posed by high-risk behaviors like smoking and drinking.


Reference

Cheng, Wei et al. “Decreased brain connectivity in smoking contrasts with increased connectivity in drinking.” eLife vol. 8 e40765. 8 Jan. 2019, doi:10.7554/eLife.40765

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